Dr. Stephan Hacker

Dr. Stephan Hacker

Stephan Hacker studies the target proteins of covalent inhibitors proteome-wide with resolution of the addressed binding pocket using mass spectrometry, focusing on applications of this technology to identify new druggable targets for antibiotics.

Selected publications

P. R. A. Zanon, F. Yu, P. Musacchio, L. Lewald, M. Zollo, K. Krauskopf, D. Mrdović, P. Raunft, T. E. Maher, M. Cigler, C. Chang, K. Lang, F. D. Toste, A. I. Nesvizhskii, S. M. Hacker,# “Profiling the Proteome-Wide Selectivity of Diverse Electrophiles”, ChemRxiv, 2021, doi.org/10.26434/chemrxiv-2021-w7rss-v2

K. Bach,* B. Beerkens,* P. R. A. Zanon,* S. M. Hacker,# "Light-activatable, 2,5-Disubstituted Tetrazoles for the Proteome-wide Profiling of Aspartates and Glutamates in Living Bacteria”, ACS Cent. Sci., 2020, 6, 546.

P. R. A. Zanon, L. Lewald, S. M. Hacker,# “Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome“, Angew. Chem. Int. Ed., 2020, 59, 2829.

S. M. Hacker,#,* K. M. Backus, #,* M. Lazear, S. Forli, B. Correia, B. F. Cravatt,# “Global Profiling of Lysine Reactivity and Ligandability in the Human Proteome“, Nat. Chem., 2017, 9, 1181.

Stephan Hacker - Fighting resistant bacteria